Publications
Deep learning enables real-time cell force measurement in fibrous matrices
A Padhi, A Daw, M Sawhney, MM Talukder, A Agashe, M Mohammad Hossein Pour, M Jafari, GM. Genin, F Alisafaei, S Kale, A Karpatne, AS Nain
Submitted, 2024
Structure-mechanics principles and mechanobiology of fibrocartilage pericellular matrix: A pivotal role of type V collagen
CH Wang, M Fan, SJ Heo, SM Adams, T Li, Y Liu, Q Li, C Loebel, F Alisafaei, JA Burdick, XL Lu, DE Birk, RL Mauck, L Han
Submitted, 2024
A microengineered model of mechanical force-induced tissue remodeling in human lungs
J Paek, LR Teegala, F Alisafaei, GC Clair, JW Song, SE Park, CK Ansong, MJ Mondrinos, VB Shenoy, C Thodeti, SM Paruchuri, D Huh
Under Revision (Nature Biomedical Engineering), 2024
Expansion limits of meshed split-thickness skin grafts
H Yu, M Jafari, A Mujahid, CF Garcia, J Shah, R Sinha, Y Huang, D Shakiba, Y Hong, D Cheraghali, J Pryce, JA Sandler, EL Elson, JM Sacks, G Genin, F Alisafaei
To Appear (Acta Biomaterialia), 2024
Matrix softening controls stretch-induced cellular memory and fibroblast activation
Y Hong, X Peng, H Yu, M Jafari, D Shakiba, Y Huang, C Qu, EE Melika, AK Tawadros, A Mujahid, J Sandler, KM Pryse, JM Sacks, EL Elson, GM Genin, F Alisafaei
To Appear (Proceedings of the National Academy of Sciences (PNAS)), 2024
Tension anisotropy drives phenotypic transitions of cells via two-way cell-ECM feedback
F Alisafaei, D Shakiba, LE Iannucci, MD Davidson, KM Pryse, PG Chao, JA Burdick, SP Lake, EL Elson, VB Shenoy, GM Genin
To Appear (Nature Materials), 2024
Vimentin is a key regulator of cell mechanosensing through opposite actions on actomyosin and microtubule networks
F Alisafaei, K Mandal, R Saldanha, M Swoger, H Yang, X Shi, M Guo, H Hehnly, CA Castañeda, PA Janmey, AE Patteson, VB Shenoy
Communications Biology, 2024
A nuclear basis for mechanointelligence in cells
F Alisafaei, H Moheimani, EL Elson, GM Genin
Proceedings of the National Academy of Sciences (PNAS), 2023
Lipid droplets are intracellular mechanical stressors that impair hepatocyte function
AE Loneker, F Alisafaei, A Kant, D Li, PA Janmey, VB Shenoy, RG Wells
Proceedings of the National Academy of Sciences (PNAS), 2023
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An ex vivo culture model of kidney podocyte injury reveals mechanosensitive, synaptopodin-templating, sarcomere-like structures
S Jiang, F Alisafaei, YY Huang, Y Hong, X Peng, C Qu, P Puapatanakul, S Jain, JH Miner, GM Genin, HY Suleiman
Science Advances, 2022
Cytoskeleton-mediated alterations of nuclear mechanics by extracellular mechanical signals
X Peng, Y Huang, F Alisafaei
Biophysical Journal, 2022
Surface-directed engineering of tissue anisotropy in microphysiological models of musculoskeletal tissue
MJ Mondrinos, F Alisafaei, AY Yi, H Ahmadzadeh, I Lee, C Blundell, J Seo, M Osborn, TJ Jeon, SM Kim, VB Shenoy, D Huh
Science Advances, 2021
The nuclear piston activates mechanosensitive ion channels to generate cell migration paths in confining microenvironments
H-P Lee, F Alisafaei, K Adebawale, J Chang, V B Shenoy, O Chaudhuri
Science Advances, 2021
Long-range mechanical signaling in biological systems
F Alisafaei, X Chen, T Leahy, P A Janmey, VB Shenoy
Soft Matter, 2021
Mechanisms of local stress amplification in axons near the gray-white matter interface
F Alisafaei, Z Gong, VE Johnson, JP Dollé, DH Smith, VB Shenoy
Biophysical Journal, 2020
Nuclear mechanics within intact cells is regulated by cytoskeletal network and internal nanostructures
J Zhang, F Alisafaei, M Nikolić, XA Nou, H Kim, VB Shenoy, G Scarcelli
Small, 2020
The balance between actomyosin contractility and microtubule polymerization regulates hierarchical protrusions that govern efficient fibroblast–collagen interactions
D Shakiba, F Alisafaei, A Savadipour, RA Rowe, Z Liu, KM Pryse, VB Shenoy, EL Elson, GM Genin
ACS Nano, 2020
Multiscale reverse engineering of the human ocular surface
J Seo, WY Byun, F Alisafaei, A Georgescu, YS Yi, M Massaro-Giordano, VB Shenoy, V Lee, VY Bunya, D Huh
Nature Medicine, 2019
Regulation of nuclear architecture, mechanics, and nucleocytoplasmic shuttling of epigenetic factors by cell geometric constraints
F Alisafaei, DS Jokhun, GV Shivashankar, VB Shenoy
Proceedings of the National Academy of Sciences (PNAS), 2019
Fiber Diameter-Dependent Elastic Deformation in Polymer Composites—A Numerical Study
N Garg, G Chandrashekar, F Alisafaei, CS Han
Journal of Engineering Materials and Technology, 2019
Compressive force induces reversible chromatin condensation and cell geometry–dependent transcriptional response
K Damodaran, S Venkatachalapathy, F Alisafaei, AV Radhakrishnan, DS Jokhun, VB Shenoy, GV Shivashankar
Molecular Biology of the Cell, 2018
Fibrous nonlinear elasticity enables positive mechanical feedback between cells and ECMs
MS Hall, F Alisafaei, E Ban, X Feng, CY Hui, VB Shenoy, M Wu
Proceedings of the National Academy of Sciences (PNAS), 2016
Length scale dependence in elastomers–comparison of indentation experiments with numerical simulations
N Garg, CS Han, F Alisafaei
Polymer, 2016
On thresholds in the indentation size effect of polymers
AN Bucsek, F Alisafaei, CS Han, N Lakhera
Polymer Bulletin, 2016
On couple-stress elasto-plastic constitutive frameworks for glassy polymers
F Alisafaei, CS Han, N Garg
International Journal of Plasticity, 2016
On the origin of indentation size effects and depth dependent mechanical properties of elastic polymers
CS Han, SHR Sanei, F Alisafaei
Journal of Polymer Engineering, 2016
Length scale dependent deformation in natural rubber
G Chandrashekar, F Alisafaei, CS Han
Journal of Applied Polymer Science, 2015
Indentation depth dependent mechanical behavior in polymers
F Alisafaei, CS Han
Advances in Condensed Matter Physics, 2015
Characterization of indentation size effects in epoxy
F Alisafaei, CS Han, N Lakhera
Polymer testing, 2014
A semi-analytical approach for the interaction of carbon nanotori
F Alisafaei, R Ansari, A Alipour
Physica E: Low-dimensional Systems and Nanostructure, 2014
On the time and indentation depth dependence of hardness, dissipation and stiffness in polydimethylsiloxane
F Alisafaei, CS Han, SHR Sanei
Polymer Testing, 2013
Dynamic analysis of heterogeneous pressure vessels subjected to thermomechanical loads
F Alisafaei, R Ansari
Journal of Pressure Vessel Technology, 2012
On the van der Waals interaction of carbon nanocones
R Ansari, F Alisafaei, A Alipour, E Mahmoudinezhad
Journal of Physics and Chemistry of Solids, 2012
Force distribution and offset configuration for carbon nanotubes
F Alisafaei, R Ansari, H Rouhi
International Journal of Nanoscience, 2012
Continuum modeling of van der Waals interaction force between carbon nanocones and carbon nanotubes
F Alisafaei, R Ansari, H Rouhi
Journal of Nanotechnology in Engineering and Medicine, 2011
Mechanics of concentric carbon nanotubes: Interaction force and suction energy
F Alisafaei, R Ansari
Computational Materials Science, 2011
Dynamic analysis of multi-layered filament-wound composite pipes subjected to cyclic internal pressure and cyclic temperature
R Ansari, F Alisafaei, P Ghaedi
Composite Structures, 2010